Network diagrams

Highlighting differences in protein networks and pathways as stem cells differentiate from pluripotent stem cells to neural stem cells.

Phosphorylated in Embryonic Stem Cells Only

Network of phosphorylated proteins detected only in embryonic stem cells (ESCs).

  • TRIAD ubiquitin ligase
  • NFkB
  • RNA polymerase II
  • AP1
  • Estrogen receptor
  • TGF-beta signaling

Embryonic Stem Cell Upregulated

Network of proteins upregulated >2.5 fold in ESCs compared to NSCs.

  • Mitotic checkpoint
  • NuA4 histone acetlytransferase
  • Glucocorticoid receptor
  • EGFR signaling
  • PI3K signaling
  • Anaphase promoting complex
  • DNA repair

Neural Stem Cell Upregulated

Network of proteins upregulated >2.5 fold in NSCs compared to ESCs.

  • DNA damage/repair
  • Mediator complex
  • AMPK, glycogen metabolism
  • Ephrin-Scr signaling
  • TGF-beta signaling
  • Neuroligin signaling
  • Histone methylation/acetylation
  • CUL4/DDB1 complex
  • Fragile X mental retardation
  • SWI/SNF, nuclear receptor coactivation
  • RNA polymerase I
  • Eye development

Phosphorylated in Neural Stem Cell Only

Network of phosporylated proteins detected only in neural stem cells (NSCs).

  • TRIAD ubiquitin
  • Anaphase promoting complex
  • TGF-beta signaling